| http://purl.uniprot.org/citations/21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21670277 | http://www.w3.org/2000/01/rdf-schema#comment | "The random nature of T-cell receptor-β (TCR-β) recombination needed to generate immunological diversity dictates that two-thirds of alleles will be out-of-frame. Transcripts derived from nonproductive rearrangements are cleared by the nonsense-mediated mRNA decay (NMD) pathway, the process by which cells selectively degrade transcripts harboring premature termination codons. Here, we demonstrate that the fetal thymus in transgenic mice that ubiquitously express a dominant-negative form of Rent1/hUpf1, an essential trans-effector of NMD, shows decreased cell number, reduced CD4CD8 double-positive thymocytes, diminished expression of TCR-β, and increased expression of CD25, suggesting a defect in pre-TCR signaling. Transgenic fetal thymocytes also demonstrated diminished endogenous Vβ-to-DβJβ rearrangements, whereas Dβ-to-Jβ rearrangements were unperturbed, suggesting that inhibition of NMD induces premature shut-off of TCR-β rearrangement. Developmental arrest of thymocytes is prevented by the introduction of a fully rearranged TCR-β transgene that precludes generation of out-of-frame transcripts, suggesting direct mRNA-mediated trans-dominant effects. These data document that NMD has been functionally incorporated into developmental programs during eukaryotic evolution."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1019352108"xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Lutz J."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Dietz H.C."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Guerrerio A.L."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Montgomery R.A."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Warren D.S."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Cooke S.K."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Frischmeyer-Guerrerio P.A."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/author | "Sonnenday C.J."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/pages | "10638-10643"xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/title | "Perturbation of thymocyte development in nonsense-mediated decay (NMD)-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21670277 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21670277 |
| http://purl.uniprot.org/citations/21670277 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21670277 |
| http://purl.uniprot.org/uniprot/#_D3YY48-mappedCitation-21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21670277 |
| http://purl.uniprot.org/uniprot/#_J3QP71-mappedCitation-21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21670277 |
| http://purl.uniprot.org/uniprot/#_P18572-mappedCitation-21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21670277 |
| http://purl.uniprot.org/uniprot/#_O55107-mappedCitation-21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21670277 |
| http://purl.uniprot.org/uniprot/#_O55108-mappedCitation-21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21670277 |
| http://purl.uniprot.org/uniprot/#_K3W4Q8-mappedCitation-21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21670277 |
| http://purl.uniprot.org/uniprot/#_Q8BPE3-mappedCitation-21670277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21670277 |