| http://purl.uniprot.org/citations/21673970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21673970 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(2+) mediates the functional coupling between L-type Ca(2+) channel (LTCC) and sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR), participating in key pathophysiological processes. This crosstalk manifests as the orthograde Ca(2+)-induced Ca(2+)-release (CICR) mechanism triggered by Ca(2+) influx, but also as the retrograde Ca(2+)-dependent inactivation (CDI) of LTCC, which depends on both Ca(2+) permeating through the LTCC itself and on SR Ca(2+) release through the RyR. This latter effect has been suggested to rely on local rather than global Ca(2+) signaling, which might parallel the nanodomain control of CDI carried out through calmodulin (CaM). Analyzing the CICR in catecholaminergic polymorphic ventricular tachycardia (CPVT) mice as a model of RyR-generated Ca(2+) leak, we evidence here that increased occurrence of the discrete local SR Ca(2+) releases through the RyRs (Ca(2+) sparks) cause a depolarizing shift in activation and a hyperpolarizing shift in isochronic inactivation of cardiac LTCC current resulting in the reduction of window current. Both increasing fast [Ca(2+)](i) buffer capacity or depleting SR Ca(2+) store blunted these changes, which could be reproduced in WT cells by RyRCa(2+) leak induced with Ryanodol and CaM inhibition.Our results unveiled a new paradigm for CaM-dependent effect on LTCC gating and further the nanodomain Ca(2+) control of LTCC, emphasizing the importance of spatio-temporal relationships between Ca(2+) signals and CaM function."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0020863"xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Richard S."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Gomez A.M."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Napolitano C."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Priori S.G."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Rueda A."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Delgado C."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Fernandez-Velasco M."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Benitah J.P."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Ruiz-Hurtado G."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Neco P."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/author | "Mercado-Morales M."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/pages | "e20863"xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/title | "RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice."xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21673970 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21673970 |
| http://purl.uniprot.org/citations/21673970 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21673970 |
| http://purl.uniprot.org/uniprot/E9Q401#attribution-02E9C53BBE78CB40DD5514250744A81A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21673970 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VJP1-mappedCitation-21673970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21673970 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VK09-mappedCitation-21673970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21673970 |
| http://purl.uniprot.org/uniprot/#_F6U7V1-mappedCitation-21673970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21673970 |