| http://purl.uniprot.org/citations/21677376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21677376 | http://www.w3.org/2000/01/rdf-schema#comment | "Glutamate transporters regulate normal synaptic network interactions and prevent neurotoxicity by rapidly clearing extracellular glutamate. GLT-1, the dominant glutamate transporter in the cerebral cortex and hippocampus, is significantly reduced in Alzheimer's disease (AD). However, the role GLT-1 loss plays in the cognitive dysfunction and pathology of AD is unknown. To determine the significance of GLT-1 dysfunction on AD-related pathological processes, mice lacking one allele for GLT-1(+/-) were crossed with transgenic mice expressing mutations of the amyloid-β protein precursor and presenilin-1 (AβPPswe/PS1ΔE9) and investigated at 6 or 9 months of age. Partial loss of GLT-1 unmasked spatial memory deficits in 6-month-old mice expressing AβPPswe/PS1ΔE9, with these mice also exhibiting an increase in the ratio of detergent-insoluble Aβ42/Aβ40. At 9 months both behavioral performance and insoluble Aβ42/Aβ40 ratios among GLT-1(+/+)/AβPPswe/PS1ΔE9 and GLT-1(+/-)/AβPPswe/PS1ΔE9 mice were comparable. These results suggest that deficits in glutamate transporter function compound the effects of familial AD AβPP/PS1 mutant transgenes in younger animals and thus may contribute to early occurring pathogenic processes associated with AD."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.org/dc/terms/identifier | "doi:10.3233/jad-2011-110503"xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Cook D.G."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Marques M.A."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Meabon J.S."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Watson G.S."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Green P.S."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Olson V.G."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Meeker K.D."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/author | "Mookherjee P."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/name | "J Alzheimers Dis"xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/pages | "447-455"xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/title | "GLT-1 loss accelerates cognitive deficit onset in an Alzheimer's disease animal model."xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/21677376 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21677376 |
| http://purl.uniprot.org/citations/21677376 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21677376 |
| http://purl.uniprot.org/uniprot/#_A2APM7-mappedCitation-21677376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21677376 |
| http://purl.uniprot.org/uniprot/#_A2APM8-mappedCitation-21677376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21677376 |
| http://purl.uniprot.org/uniprot/#_A2AQI7-mappedCitation-21677376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21677376 |
| http://purl.uniprot.org/uniprot/#_A2APL5-mappedCitation-21677376 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21677376 |