| http://purl.uniprot.org/citations/21680525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21680525 | http://www.w3.org/2000/01/rdf-schema#comment | "Resistance to small-molecule CCR5 inhibitors arises when HIV-1 variants acquire the ability to use inhibitor-bound CCR5 while still recognizing free CCR5. Two isolates, CC101.19 and D1/85.16, became resistant via four substitutions in the gp120 V3 region and three in the gp41 fusion peptide (FP), respectively. The binding characteristics of a panel of monoclonal antibodies (MAbs) imply that several antigenic forms of CCR5 are expressed at different levels on the surfaces of U87-CD4-CCR5 cells and primary CD4(+) T cells, in a cell-type-dependent manner. CCR5 binding and HIV-1 infection inhibition experiments suggest that the two CCR5 inhibitor-resistant viruses altered their interactions with CCR5 in different ways. As a result, both mutants became generally more sensitive to inhibition by CCR5 MAbs, and the FP mutant is specifically sensitive to a MAb that stains discrete cell surface clusters of CCR5 that may correspond to lipid rafts. We conclude that some MAbs detect different antigenic forms of CCR5 and that inhibitor-sensitive and -resistant viruses can use these CCR5 forms differently for entry in the presence or absence of CCR5 inhibitors."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.00767-11"xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Klasse P.J."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Moore J.P."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Sanders R.W."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Hope T.J."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Sakmar T.P."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Berro R."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Nagashima K.A."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Flegler A."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/author | "Lascano D."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/pages | "8227-8240"xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/title | "Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors."xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/21680525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21680525 |
| http://purl.uniprot.org/citations/21680525 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21680525 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-21680525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21680525 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-21680525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21680525 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-21680525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21680525 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-21680525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21680525 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-21680525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21680525 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-21680525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21680525 |