| http://purl.uniprot.org/citations/21685032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21685032 | http://www.w3.org/2000/01/rdf-schema#comment | "IκB kinase (IKKε) is a serine/threonine protein kinase that belongs to the IKK kinase family. Recent studies have shown that IKKε functions as a breast and ovarian cancer oncogene. We demonstrated frequent overexpression of IKKε in pancreatic ductal adenocarcinoma (PDA). We immunohistochemically evaluated 78 PDAs using the avidin-biotin-peroxidase method and the anti-IKKε rabbit polyclonal antibody. Elevated IKKε reactivity (immunohistochemical score, 4-9) was observed in 64% of PDAs (50/78), but in 0.0% of nonneoplastic pancreatic ductal epithelium (0/113; P < .001). Kaplan-Meier analysis of overall survival revealed that patients with high IKKε-immunohistochemical scores (4-9) had significantly shorter survival than did patients with low IKKε immunohistochemical scores (0-3; P = .023; log-rank test) independent of tumor stage or grade. These data indicate that deregulation of IKKε is a common event in PDA and might have an important role in the pathogenesis of this deadly disease. In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.org/dc/terms/identifier | "doi:10.1309/ajcp2jjgyniuas2v"xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/author | "Cheng A."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/author | "Coppola D."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/author | "Henderson-Jackson E."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/author | "Malafa M."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/name | "Am J Clin Pathol"xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/pages | "60-66"xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/title | "IkappaB Kinase epsilon expression in pancreatic ductal adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://purl.uniprot.org/core/volume | "136"xsd:string |
| http://purl.uniprot.org/citations/21685032 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21685032 |
| http://purl.uniprot.org/citations/21685032 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21685032 |
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| http://purl.uniprot.org/uniprot/#_Q14164-mappedCitation-21685032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685032 |
| http://purl.uniprot.org/uniprot/A0A075B7B4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21685032 |
| http://purl.uniprot.org/uniprot/Q14164 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21685032 |