| http://purl.uniprot.org/citations/21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21685384 | http://www.w3.org/2000/01/rdf-schema#comment | "MARS is an evolutionary conserved supramolecular assembly of aminoacyl-tRNA synthetases found in eukaryotes. This complex was thought to be ubiquitous in the deuterostome and protostome clades of bilaterians because similar complexes were isolated from arthropods and vertebrates. However, several features of the component enzymes suggested that in the nematode Caenorhabditis elegans, a species grouped with arthropods in modern phylogeny, this complex might not exist, or should display a significantly different structural organization. C. elegans was also taken as a model system to study in a multicellular organism amenable to experimental approaches, the reason for existence of these supramolecular entities. Here, using a proteomic approach, we have characterized the components of MARS in C. elegans. We show that this organism evolved a specific structural organization of this complex, which contains several bona fide components of the MARS complexes known so far, but also displays significant variations. These data highlight molecular evolution events that took place after radiation of bilaterians. Remarkably, it shows that expansion of MARS assembly in metazoans is not linear, but is the result of additions but also of subtractions along evolution. We then undertook an experimental approach, using inactivation of the endogenous copy of methionyl-tRNA synthetase by RNAi and expression of transgenic variants, to understand the role in complex assembly and the in vivo functionality, of the eukaryotic-specific domains appended to aminoacyl-tRNA synthetases. We show that rescue of the worms and assembly of transgenic variants into MARS rest on the presence of these appended domains."xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.254037"xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/author | "Mirande M."xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/author | "Havrylenko S."xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/author | "Negrutskii B."xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/author | "Legouis R."xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/pages | "28476-28487"xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans evolves a new architecture for the multi-aminoacyl-tRNA synthetase complex."xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21685384 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21685384 |
| http://purl.uniprot.org/citations/21685384 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21685384 |
| http://purl.uniprot.org/uniprot/#_A5HU89-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_O18240-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_P49041-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_D3YT56-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_D3YT95-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_D3YT96-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_G5EEC0-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_G5ECE5-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_O01802-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_O02056-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |
| http://purl.uniprot.org/uniprot/#_O02639-mappedCitation-21685384 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21685384 |