| http://purl.uniprot.org/citations/21685892 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21685892 | http://www.w3.org/2000/01/rdf-schema#comment | "The centromere-specific histone H3 variant CENH3 (also known as CENP-A) is considered to be an epigenetic mark for establishment and propagation of centromere identity. Pulse induction of CENH3 (Drosophila CID) in Schneider S2 cells leads to its incorporation into non-centromeric regions and generates CID islands that resist clearing from chromosome arms for multiple cell generations. We demonstrate that CID islands represent functional ectopic kinetochores, which are non-randomly distributed on the chromosome and show a preferential localization near telomeres and pericentric heterochromatin in transcriptionally silent, intergenic chromatin domains. Although overexpression of heterochromatin protein 1 (HP1) or increasing histone acetylation interferes with CID island formation on a global scale, induction of a locally defined region of synthetic heterochromatin by targeting HP1-LacI fusions to stably integrated Lac operator arrays produces a proximal hotspot for CID deposition. These data indicate that the characteristics of regions bordering heterochromatin promote de novo kinetochore assembly and thereby contribute to centromere identity."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2272"xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "Manke T."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "Saccani S."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "Maiato H."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "Pereira A.J."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "Diehl S."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "van Essen D."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "Heun P."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/author | "Olszak A.M."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/pages | "799-808"xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/title | "Heterochromatin boundaries are hotspots for de novo kinetochore formation."xsd:string |
| http://purl.uniprot.org/citations/21685892 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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