| http://purl.uniprot.org/citations/21693575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21693575 | http://www.w3.org/2000/01/rdf-schema#comment | "S100B protein has been shown to exert anti-myogenic and mitogenic effects in myoblast cultures through inhibition of the myogenic p38 MAPK and activation of the mitogenic ERK1/2. However, the receptor mediating these effects had not been identified. Here, we show that S100B increases and/or stabilizes the binding of basic fibroblast growth factor (bFGF) to bFGF receptor 1 (FGFR1) by interacting with bFGF, thereby enhancing FGFR1 activation and the mitogenic and anti-myogenic effects of FGFR1. S100B also binds to its canonical receptor RAGE (receptor for advanced glycation end-products), a multi-ligand receptor previously shown to transduce a pro-myogenic signal when activated by HMGB1, and recruits RAGE into a RAGE-S100B-bFGF-FGFR1 complex. However, when bound to S100B-bFGF-FGFR1, RAGE can no longer stimulate myogenic differentiation, whereas in the absence of either bFGF or FGFR1, binding of S100B to RAGE results in stimulation of RAGE anti-mitogenic and promyogenic signaling. An S100B-bFGF-FGFR1 complex also forms in Rage(-/-) myoblasts, leading to enhanced proliferation and reduced differentiation, which points to a dispensability of RAGE for the inhibitory effects of S100B on myoblasts under the present experimental conditions. These results reveal a new S100B-interacting protein - bFGF - in the extracellular milieu and suggest that S100B stimulates myoblast proliferation and inhibits myogenic differentiation by activating FGFR1 in a bFGF-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.084491"xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/author | "Donato R."xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/author | "Sorci G."xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/author | "Riuzzi F."xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/pages | "2389-2400"xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/title | "S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/21693575 | http://purl.uniprot.org/core/volume | "124"xsd:string |
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