| http://purl.uniprot.org/citations/21700224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21700224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21700224 | http://www.w3.org/2000/01/rdf-schema#comment | "We present a molecular dissection of pause site-dependent transcriptional termination for mammalian RNA polymerase II (Pol II)-transcribed genes. We show that nascent transcripts form RNA/DNA hybrid structures (R-loops) behind elongating Pol II and are especially prevalent over G-rich pause sites positioned downstream of gene poly(A) signals. Senataxin, a helicase protein associated with AOA2/ALS4 neurodegenerative disorders, acts to resolve these R-loop structures and by so doing allows access of the 5'-3' exonuclease Xrn2 at 3' cleavage poly(A) sites. This affords 3' transcript degradation and consequent Pol II termination. In effect, R-loops formed over G-rich pause sites, followed by their resolution by senataxin, are key steps in the termination process."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.04.026"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.04.026"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/author | "Proudfoot N.J."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/author | "Proudfoot N.J."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/author | "Gromak N."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/author | "Gromak N."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/author | "Skourti-Stathaki K."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/author | "Skourti-Stathaki K."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/pages | "794-805"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/pages | "794-805"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/title | "Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/title | "Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination."xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/21700224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21700224 |
| http://purl.uniprot.org/citations/21700224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21700224 |
| http://purl.uniprot.org/citations/21700224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21700224 |
| http://purl.uniprot.org/citations/21700224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21700224 |