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| http://purl.uniprot.org/citations/21707761 | http://www.w3.org/2000/01/rdf-schema#comment | "CCL27 and CCL17 are chemokines believed to be involved in the process of establishing the inflammatory infiltrate, characteristic for the various inflammatory skin diseases. The skin-specific CCL27 binds the chemokine receptor-10 (CCR10), and CCL17 is a chemokine receptor-4 (CCR4) ligand. The purpose of our study was to characterize the expression of CCL27 and CCL17 in the inflammatory skin diseases: psoriasis, atopic dermatitis (AD) and acute allergic contact dermatitis (ACD) induced in nickel-sensitive individuals. Surprisingly, our studies revealed a markedly decreased CCL27 mRNA and protein expression in psoriatic lesions compared with non-lesional psoriatic skin. A minor CCL17 mRNA increase was measured in lesional psoriatic skin. No alterations were found in AD. In ACD, we found a pronounced (90-fold) raise in CCL17 mRNA and a 50-fold increase in CCL17 protein compared with normal skin. A kinetic ACD study of CCL17 expression showed the highest mean value 24 h after hapten application. Furthermore, we found the mRNA levels of CCR10 and CCR4 paralleling the results of their corresponding ligands. Overall, our principal findings were a distinct decrease in CCL27 in lesional psoriatic skin and a marked upregulation of CCL17 in ACD. These findings underscore the differential cutaneous T-cell recruitment in different inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0625.2011.01323.x"xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/author | "Johansen C."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/author | "Iversen L."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/author | "Vestergaard C."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/author | "Kragballe K."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/author | "Riis J.L."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/author | "Bech R."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/name | "Exp Dermatol"xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/pages | "789-794"xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/title | "Kinetics and differential expression of the skin-related chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic contact dermatitis."xsd:string |
| http://purl.uniprot.org/citations/21707761 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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