| http://purl.uniprot.org/citations/21710262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21710262 | http://www.w3.org/2000/01/rdf-schema#comment | "Identification of cytotoxic T lymphocyte (CTL) epitopes from tumor antigens is essential for the development of peptide vaccines against tumor immunotherapy. Among all the tumor antigens, the caner-testis (CT) antigens are the most widely studied and promising targets. PLAC1 (placenta-specific 1, CT92) was considered as a novel member of caner-testis antigen, which expressed in a wide range of human malignancies, most frequently in breast cancer. In this study, three native peptides and their analogues derived from PLAC1 were predicted by T cell epitope prediction programs including SYFPEITHI, BIMAS and NetCTL 1.2. Binding affinity and stability assays in T2 cells showed that two native peptides, p28 and p31, and their analogues (p28-1Y9 V, p31-1Y2L) had more potent binding activity towards HLA-A*0201 molecule. In ELISPOT assay, the CTLs induced by these four peptides could release IFN-γ. The CTLs induced by these four peptides from the peripheral blood mononuclear cells (PBMCs) of HLA-A*02+ healthy donor could lyse MCF-7 breast cancer cells (HLA-A*0201+, PLAC1+) in vitro. When immunized in HLA-A2.1/Kb transgenic mice, the peptide p28 could induce the most potent peptide-specific CTLs among these peptides. Therefore, our results indicated that the peptide p28 (VLCSIDWFM) could serve as a novel candidate epitope for the development of peptide vaccines against PLAC1-positive breast cancer."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00726-011-0966-3"xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Qi Y."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Sun M."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Zhai M."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/author | "Dai C."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/name | "Amino Acids"xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/pages | "2257-2265"xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/title | "Identification of a novel HLA-A2-restricted cytotoxic T lymphocyte epitope from cancer-testis antigen PLAC1 in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/21710262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21710262 |
| http://purl.uniprot.org/citations/21710262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21710262 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-21710262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21710262 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-21710262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21710262 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-21710262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21710262 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-21710262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21710262 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-21710262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21710262 |