| http://purl.uniprot.org/citations/21712833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21712833 | http://www.w3.org/2000/01/rdf-schema#comment | "In mouse hippocampal CA1 pyramidal neurons, the activity of synaptic small-conductance Ca(2+)-activated K(+) channels type 2 (SK2 channels) provides a negative feedback on N-methyl-D-aspartate receptors (NMDARs), reestablishing Mg(2+) block that reduces Ca(2+) influx. The well-established role of NMDARs in ischemia-induced excitotoxicity led us to test the neuroprotective effect of modulating SK2 channel activity following cerebral ischemia induced by cardiac arrest and cardiopulmonary resuscitation (CA/CPR). Administration of the SK channel positive modulator, 1-ethyl-benzimidazolinone (1-EBIO), significantly reduced CA1 neuron cell death and improved CA/CPR-induced cognitive outcome. Electrophysiological recordings showed that CA/CPR-induced ischemia caused delayed and sustained reduction of synaptic SK channel activity, and immunoelectron microscopy showed that this is associated with internalization of synaptic SK2 channels, which was prevented by 1-EBIO treatment. These results suggest that increasing SK2 channel activity, or preventing ischemia-induced loss of synaptic SK2 channels, are promising and novel approaches to neuroprotection following cerebral ischemia."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.org/dc/terms/identifier | "doi:10.1038/jcbfm.2011.90"xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Nakayama S."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Adelman J.P."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Lujan R."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Kuroiwa M."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Maylie J."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Allen D."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Bond C.T."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Kosaka Y."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Ballesteros C."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Herson P.S."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/author | "Palmateer J."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/name | "J Cereb Blood Flow Metab"xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/pages | "2302-2312"xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/title | "SK2 channels are neuroprotective for ischemia-induced neuronal cell death."xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21712833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21712833 |
| http://purl.uniprot.org/citations/21712833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21712833 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT12-mappedCitation-21712833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21712833 |
| http://purl.uniprot.org/uniprot/#_B4YDY0-mappedCitation-21712833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21712833 |