| http://purl.uniprot.org/citations/21717483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21717483 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo assess first trimester placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) as screening markers for early-onset pre-eclampsia (PE) and intra-uterine growth restriction (IUGR).MethodsPlGF concentration was retrospectively measured in first trimester serum specimens of 23 cases of early-onset PE (<34 weeks), 26 cases of IUGR (birth weight < 5th centile) and 5 controls per case. Levels were adjusted for gestational age (GA), ethnicity and smoking to obtain multiples of the expected median (MoM). Logistic regression was used to assess PlGF, PAPP-A and maternal characteristics as potential predictors of early-onset PE and IUGR.ResultsPlGF MoM levels were significantly lower in the early-onset PE group (P < 0.0001) compared with controls, but not in the IUGR group. PAPP-A MoM levels were significantly lower in the IUGR group (P < 0.01) compared with controls but not in the early-onset PE group. PlGF significantly improved the ability of systolic blood pressure at the first prenatal visit to predict early-onset PE [achieving a receiver-operating characteristics curve with area under the curve (AUC) of 0.8]. Combining systolic blood pressure at the first prenatal visit and PlGF did not significantly improve the predictive ability compared with PlGF alone (AUC = 0.83).ConclusionSerum PlGF is an acceptable marker in first trimester screening for early-onset PE, but a poor marker in screening for IUGR. Screening performance of serum PAPP-A is poor for both early-onset PE and IUGR."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.org/dc/terms/identifier | "doi:10.1002/pd.2807"xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/author | "Blankenstein M.A."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/author | "Twisk J.W."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/author | "van Vugt J.M."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/author | "Heijboer A.C."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/author | "Mensink I."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/author | "Vandenberghe G."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/name | "Prenat Diagn"xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/pages | "955-961"xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/title | "First trimester screening for intra-uterine growth restriction and early-onset pre-eclampsia."xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21717483 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21717483 |
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| http://purl.uniprot.org/uniprot/#_P49763-mappedCitation-21717483 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21717483 |
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