| http://purl.uniprot.org/citations/21723284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21723284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21723284 | http://www.w3.org/2000/01/rdf-schema#comment | "Nel-like protein 1 (NELL-1) is an osteoinductive molecule associated with premature calvarial suture closure. Here we identified apoptosis related protein 3 (APR3), a membrane protein known as a proliferation suppressor, as a binding protein of NELL-1 by biopanning. NELL-1 and APR3 colocalized on the nuclear envelope of human osteoblasts. NELL-1 significantly inhibited proliferation of osteoblasts co-transfected with APR3 through further down-regulation of Cyclin D1. The co-expression of NELL-1 and APR3 enhanced Ocn and Bsp expression and mineralization. RNAi of APR3 significantly reduced the differentiation effect of NELL-1. These findings suggest that the effects of NELL-1 on osteoblastic differentiation and proliferation are partly through binding to APR3."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.06.024"xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.06.024"xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Pang S."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Pang S."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Shen J."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Shen J."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zou X."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zou X."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Adams J.S."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Adams J.S."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Soo C."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Soo C."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Ting K."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Ting K."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zara J.N."xsd:string |
| http://purl.uniprot.org/citations/21723284 | http://purl.uniprot.org/core/author | "Zara J.N."xsd:string |