| http://purl.uniprot.org/citations/21724589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21724589 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunosuppressive cytokines subvert innate and adaptive immune responses during cancer progression. The inflammatory cytokine interleukin-18 (IL-18) is known to accumulate in cancer patients, but its pathophysiological role remains unclear. In this study, we show that low levels of circulating IL-18, either exogenous or tumor derived, act to suppress the NK cell arm of tumor immunosurveillance. IL-18 produced by tumor cells promotes the development of NK-controlled metastases in a PD-1-dependent manner. Accordingly, PD-1 is expressed by activated mature NK cells in lymphoid organs of tumor bearers and is upregulated by IL-18. RNAi-mediated knockdown of IL-18 in tumors, or its systemic depletion by IL-18-binding protein, are sufficient to stimulate NK cell-dependent immunosurveillance in various tumor models. Together, these results define IL-18 as an immunosuppressive cytokine in cancer. Our findings suggest novel clinical implementations of anti-PD-1 antibodies in human malignancies that produce IL-18."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-11-0993"xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Meinhardt K."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Kroemer G."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Ryffel B."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Schultze J.L."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Desbois M."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Tartour E."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Ullrich E."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Prevost-Blondel A."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Zitvogel L."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Delahaye N."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Chaput N."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Terme M."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Kaplanski G."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Viaud S."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/author | "Aymeric L."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/pages | "5393-5399"xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/title | "IL-18 induces PD-1-dependent immunosuppression in cancer."xsd:string |
| http://purl.uniprot.org/citations/21724589 | http://purl.uniprot.org/core/volume | "71"xsd:string |