| http://purl.uniprot.org/citations/21729782 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21729782 | http://www.w3.org/2000/01/rdf-schema#comment | "Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of paused polymerase into productive elongation has emerged as a major mechanism of transcription activation. Reactivation of paused Pol II correlates with recruitment of super-elongation complexes (SECs) containing ELL/EAF family members, P-TEFb, and other proteins, but the mechanism of their recruitment is an unanswered question. Here, we present evidence for a role of human Mediator subunit MED26 in this process. We identify in the conserved N-terminal domain of MED26 overlapping docking sites for SEC and a second ELL/EAF-containing complex, as well as general initiation factor TFIID. In addition, we present evidence consistent with the model that MED26 can function as a molecular switch that interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexes containing ELL/EAF and P-TEFb to facilitate transition of Pol II into the elongation stage of transcription."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.06.005"xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Florens L."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Washburn M.P."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Swanson S.K."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Conaway J.W."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Conaway R.C."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Parmely T.J."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Tomomori-Sato C."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Martin-Brown S."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Shilatifard A."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Smith E.R."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Banks C.A."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Kong S.E."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Seidel C.W."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/author | "Szutorisz H."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/pages | "92-104"xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/title | "Human mediator subunit MED26 functions as a docking site for transcription elongation factors."xsd:string |
| http://purl.uniprot.org/citations/21729782 | http://purl.uniprot.org/core/volume | "146"xsd:string |