| http://purl.uniprot.org/citations/21733318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21733318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21733318 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of the present study was to evaluate the effect of a chronic oral γ-conglutin treatment in male Sprague-Dawley rats in which hyperglycaemia had been induced by supplying 10 % d-glucose in drinking-water. A γ-conglutin dosage of 28 mg/kg body weight was daily administered to animals for 21 d. Plasma glucose, insulin and glucose overloading were monitored. Chronic administration of glucose resulted in a statistically significant (P < 0·05) increase in fasting blood glucose (2·5-fold) and insulin (2·7-fold) v. the values recorded in control rats. Simultaneous treatment with γ-conglutin attenuated the rise in plasma glucose (1·9-fold) and insulin (1·8-fold) levels in the glucose-fed rats (P < 0·05). Fasting insulin and homeostasis model of insulin resistance were decreased by 34 and 48 % (P < 0·05), respectively, in the γ-conglutin-treated rats v. the values found in pair-fed animals. To confirm these results with a different approach, HepG2 cells, grown for 24 and 48 h in Dulbecco's minimum essential medium containing different glucose concentrations (5·5, 11·1 and 16·5 mmol/l), were exposed to 10 μmol/l γ-conglutin with or without 10 mmol/l metformin or 100 nmol/l insulin. γ-Conglutin increased glucose consumption (from 1·5-to 2·5-fold) in HepG2 cells, under all experimental conditions; this effect was more evident after 48 h incubation. Moreover, in this in vitro model, the addition of γ-conglutin potentiated the activity of insulin and metformin in cell glucose consumption. These findings extend the previous ones and suggest the potential use of lupin γ-conglutin in the control of glycaemia."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.org/dc/terms/identifier | "doi:10.1017/s0007114511002601"xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.org/dc/terms/identifier | "doi:10.1017/s0007114511002601"xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Duranti M."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Duranti M."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Magni C."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Magni C."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Castiglioni S."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Castiglioni S."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Lovati M.R."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Lovati M.R."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Manzoni C."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Manzoni C."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Parolari A."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/author | "Parolari A."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/name | "Br. J. Nutr."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/name | "Br. J. Nutr."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/pages | "67-73"xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/pages | "67-73"xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/title | "Lupin seed gamma-conglutin lowers blood glucose in hyperglycaemic rats and increases glucose consumption of HepG2 cells."xsd:string |
| http://purl.uniprot.org/citations/21733318 | http://purl.uniprot.org/core/title | "Lupin seed gamma-conglutin lowers blood glucose in hyperglycaemic rats and increases glucose consumption of HepG2 cells."xsd:string |