| http://purl.uniprot.org/citations/21734642 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21734642 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the availability of several large-scale proteomics studies aiming to identify protein interactions on a global scale, little is known about how proteins interact and are organized within macromolecular complexes. Here, we describe a technique that consists of a combination of biochemistry approaches, quantitative proteomics and computational methods using wild-type and deletion strains to investigate the organization of proteins within macromolecular protein complexes. We applied this technique to determine the organization of two well-studied complexes, Spt-Ada-Gcn5 histone acetyltransferase (SAGA) and ADA, for which no comprehensive high-resolution structures exist. This approach revealed that SAGA/ADA is composed of five distinct functional modules, which can persist separately. Furthermore, we identified a novel subunit of the ADA complex, termed Ahc2, and characterized Sgf29 as an ADA family protein present in all Gcn5 histone acetyltransferase complexes. Finally, we propose a model for the architecture of the SAGA and ADA complexes, which predicts novel functional associations within the SAGA complex and provides mechanistic insights into phenotypical observations in SAGA mutants."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.org/dc/terms/identifier | "doi:10.1038/msb.2011.40"xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Florens L."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Lee K.K."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Gilmore J.M."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Washburn M.P."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Swanson S.K."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Workman J.L."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Grant P.A."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Sardiu M.E."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/author | "Torok M."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/name | "Mol Syst Biol"xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/pages | "503"xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/title | "Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes."xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/21734642 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21734642 |
| http://purl.uniprot.org/citations/21734642 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21734642 |
| http://purl.uniprot.org/uniprot/Q12433#attribution-A11FD0E97AB75AB820C65221B3DEC27F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21734642 |
| http://purl.uniprot.org/uniprot/P25649#attribution-A11FD0E97AB75AB820C65221B3DEC27F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21734642 |
| http://purl.uniprot.org/uniprot/P25649#attribution-F6A6897398F71A770755E8E65CFB62ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21734642 |
| http://purl.uniprot.org/uniprot/P32494#attribution-A11FD0E97AB75AB820C65221B3DEC27F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21734642 |
| http://purl.uniprot.org/uniprot/Q05027#attribution-EC3900CC16DE8D0EE805E062E1754056 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21734642 |
| http://purl.uniprot.org/uniprot/P38129#attribution-EC3900CC16DE8D0EE805E062E1754056 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21734642 |