| http://purl.uniprot.org/citations/21737278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21737278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21737278 | http://www.w3.org/2000/01/rdf-schema#comment | "Although nervous systems are largely bilaterally symmetric on a structural level, they display striking degrees of functional left/right (L/R) asymmetry. In Caenorhabditis elegans, two structurally symmetric pairs of sensory neurons, ASE and AWC, display two distinctly controlled types of functional L/R asymmetries (stereotyped versus stochastic asymmetry). Beyond these two cases, the extent of neuronal asymmetry in the C. elegans nervous system was unclear. Here, we report that the Beta3/Olig-type bHLH transcription factor hlh-16 is L/R asymmetrically expressed in several distinct, otherwise bilaterally symmetric interneuron and motoneuron pairs that are part of a known navigation circuit. We find that hlh-16 asymmetry is generated during gastrulation by an asymmetric LAG-2/Delta signal originating from the mesoderm that promotes hlh-16 expression in neurons on the left side through direct binding of the Notch effector LAG-1/Su(H)/CBF to a cis-regulatory element in the hlh-16 locus. Removal of hlh-16 reveals an unanticipated asymmetry in the ability of the axons of the AIY interneurons to extend into the nerve ring, with the left AIY axon requiring elevated hlh-16 expression for correct extension. Our study suggests that the extent of molecular L/R asymmetry in the C. elegans nervous system is broader than previously anticipated, establishes a novel signaling mechanism that crosses germ layers to diversify bilaterally symmetric neuronal lineages, and reveals L/R asymmetric control of axonal outgrowth of bilaterally symmetric neurons."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2011.06.016"xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2011.06.016"xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Hobert O."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Hobert O."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Poole R.J."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Poole R.J."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Bertrand V."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Bertrand V."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Bisso P."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/author | "Bisso P."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/pages | "1225-1231"xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/pages | "1225-1231"xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/title | "Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneurons."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/title | "Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneurons."xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/21737278 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21737278 |
| http://purl.uniprot.org/citations/21737278 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21737278 |