| http://purl.uniprot.org/citations/21738214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21738214 | http://www.w3.org/2000/01/rdf-schema#comment | "Alkylating DNA-damage agents such as N-methyl-N'-nitro-N'-nitrosoguanidine (MNNG) trigger necroptosis, a newly defined form of programmed cell death (PCD) managed by receptor interacting protein kinases. This caspase-independent mode of cell death involves the sequential activation of poly(ADP-ribose) polymerase-1 (PARP-1), calpains, BAX and AIF, which redistributes from mitochondria to the nucleus to promote chromatinolysis. We have previously demonstrated that the BAX-mediated mitochondrial release of AIF is a critical step in MNNG-mediated necroptosis. However, the mechanism regulating BAX activation in this PCD is poorly understood. Employing mouse embryonic knockout cells, we reveal that BID controls BAX activation in AIF-mediated necroptosis. Indeed, BID is a link between calpains and BAX in this mode of cell death. Therefore, even if PARP-1 and calpains are activated after MNNG treatment, BID genetic ablation abolishes both BAX activation and necroptosis. These PCD defects are reversed by reintroducing the BID-wt cDNA into the BID(-/-) cells. We also demonstrate that, after MNNG treatment, BID is directly processed into tBID by calpains. In this way, calpain non-cleavable BID proteins (BID-G70A or BID-Δ68-71) are unable to promote BAX activation and necroptosis. Once processed, tBID localizes in the mitochondria of MNNG-treated cells, where it can facilitate BAX activation and PCD. Altogether, our data reveal that, as in caspase-dependent apoptosis, BH3-only proteins are key regulators of caspase-independent necroptosis."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2011.91"xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Cabon L."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Lorenzo H.K."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Susin S.A."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Gross A."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Bouharrour A."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Galan-Malo P."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Delavallee L."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/author | "Brunelle-Navas M.N."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/pages | "245-256"xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/title | "BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation."xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/21738214 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21738214 |
| http://purl.uniprot.org/citations/21738214 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21738214 |
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| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-21738214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738214 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT35-mappedCitation-21738214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738214 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT81-mappedCitation-21738214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738214 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA4-mappedCitation-21738214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738214 |
| http://purl.uniprot.org/uniprot/#_A0A165ELP6-mappedCitation-21738214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738214 |
| http://purl.uniprot.org/uniprot/#_A0A494BBC4-mappedCitation-21738214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738214 |