| http://purl.uniprot.org/citations/21738688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21738688 | http://www.w3.org/2000/01/rdf-schema#comment | "G protein-coupled receptors (GPCRs) activate mitogen-activated protein kinases through a number of distinct pathways in cells. Increasing evidence has suggested that endosomal signaling has an important role in receptor signal transduction. Here we investigated the involvement of endocytosis in α(1A)-adrenergic receptor (α(1A)-AR)-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2). Agonist-mediated endocytic traffic of α(1A)-AR was assessed by real-time imaging of living, stably transfected human embryonic kidney 293A cells (HEK-293A). α(1A)-AR was internalized dynamically in cells with agonist stimulation, and actin filaments regulated the initial trafficking of α(1A)-AR. α(1A)-AR-induced activation of ERK1/2 but not p38 MAPK was sensitive to disruption of endocytosis, as demonstrated by 4°C chilling, dynamin mutation and treatment with cytochalasin D (actin depolymerizing agent). Activation of protein kinase C (PKC) and C-Raf by α(1A)-AR was not affected by 4°C chilling or cytochalasin D treatment. U73122 (a phospholipase C [PLC] inhibitor) and Ro 31-8220 (a PKC inhibitor) inhibited α(1B)-AR-but not α(1A)-AR-induced ERK1/2 activation. These data suggest that the endocytic pathway is involved in α(1A)-AR-induced ERK1/2 activation, which is independent of G(q)/PLC/PKC signaling."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0021520"xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Han Q."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Liang Z."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "Xu N."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/author | "He K."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/pages | "e21520"xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/title | "alpha1A-adrenergic receptor induces activation of extracellular signal-regulated kinase 1/2 through endocytic pathway."xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21738688 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21738688 |
| http://purl.uniprot.org/citations/21738688 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21738688 |
| http://purl.uniprot.org/uniprot/#_B0ZBD3-mappedCitation-21738688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738688 |
| http://purl.uniprot.org/uniprot/#_P35348-mappedCitation-21738688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738688 |
| http://purl.uniprot.org/uniprot/#_Q7KYZ9-mappedCitation-21738688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738688 |
| http://purl.uniprot.org/uniprot/#_Q6LD06-mappedCitation-21738688 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21738688 |
| http://purl.uniprot.org/uniprot/Q7KYZ9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21738688 |
| http://purl.uniprot.org/uniprot/P35348 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21738688 |