| http://purl.uniprot.org/citations/21741997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21741997 | http://www.w3.org/2000/01/rdf-schema#comment | "Breast cancer is a leading cause of morbidity in women worldwide. neutrophil gelatinase-associated lipocalin (NGAL), a useful biomarker of ER negative (ER(-)) breast cancer, promotes local tumor invasion and lymph node metastasis. We first identified the distinctive expression of NGAL in two breast cancer cell lines MCF7 and MDA-MB-231 cells, and then confirmed NGAL as a critical inducer of metastasis. Finally, the transcriptional factor CCAAT enhancer-binding proteins ζ (C/EBP ζ) was overexpressed in MDA-MB-231 cells. Consistent with the effect of NGAL knockdown, C/EBP ζ overexpression caused the significant changes that could prevent cell metastasis. C/EBP ζ overexpression induced a strong decrease in NGAL and matrix metalloproteinases (MMPs) expressions as determined by quantitative real time PCR and Western blotting. To identify the potential role of C/EBP ζ on regulating of NGAL in breast cancer, we established the dual-luciferase reporter assay for NGAL in MDA-MB-231 cells cotransfected with C/EBP ζ. Promoter reporter assays determined that C/EBP ζ directly repressed the human NGAL gene promoter activity by inhibiting the NGAL transcription. Taken together, this work identified that the C/EBP ζ overexpression downregulated NGAL to inhibit migration and invasion of breast cancer, which could be used as a novel strategy for breast cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2011.06.010"xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Jin W."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Gao W."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Ma L."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Lin Y."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Chang G."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/author | "Pang T."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/pages | "1803-1813"xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/title | "C/EBP zeta targets to neutrophil gelatinase-associated lipocalin (NGAL) as a repressor for metastasis of MDA-MB-231 cells."xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://purl.uniprot.org/core/volume | "1813"xsd:string |
| http://purl.uniprot.org/citations/21741997 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21741997 |
| http://purl.uniprot.org/citations/21741997 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21741997 |
| http://purl.uniprot.org/uniprot/#_B2ZDQ1-mappedCitation-21741997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21741997 |
| http://purl.uniprot.org/uniprot/#_P35638-mappedCitation-21741997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21741997 |
| http://purl.uniprot.org/uniprot/#_P0DPQ6-mappedCitation-21741997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21741997 |
| http://purl.uniprot.org/uniprot/#_P80188-mappedCitation-21741997 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21741997 |