| http://purl.uniprot.org/citations/21746876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21746876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21746876 | http://www.w3.org/2000/01/rdf-schema#comment | "Stomatin-like protein 2 (SLP-2) is a widely expressed mitochondrial inner membrane protein of unknown function. Here we show that human SLP-2 interacts with prohibitin-1 and -2 and binds to the mitochondrial membrane phospholipid cardiolipin. Upregulation of SLP-2 expression increases cardiolipin content and the formation of metabolically active mitochondrial membranes and induces mitochondrial biogenesis. In human T lymphocytes, these events correlate with increased complex I and II activities, increased intracellular ATP stores, and increased resistance to apoptosis through the intrinsic pathway, ultimately enhancing cellular responses. We propose that the function of SLP-2 is to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled. Likely through the prohibitin functional interactome, SLP-2 then regulates mitochondrial biogenesis and function."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05393-11"xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05393-11"xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Dunn S.D."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Dunn S.D."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Chau L.A."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Chau L.A."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Madrenas J."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Madrenas J."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Hatch G.M."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Hatch G.M."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Kirchhof M.G."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Kirchhof M.G."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Ball E.H."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Ball E.H."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Christie D.A."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Christie D.A."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Elias I.M."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Elias I.M."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Lemke C.D."xsd:string |
| http://purl.uniprot.org/citations/21746876 | http://purl.uniprot.org/core/author | "Lemke C.D."xsd:string |