http://purl.uniprot.org/citations/21747906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21747906 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundRecent genome-wide association studies have identified a number of common variants associated with fasting glucose homeostasis and type 2 diabetes in populations of European origin. This is a replication study to examine whether such associations are also observed in Chinese Hans.MethodsWe genotyped nine variants in or near MADD, ADRA2A, CRY2, GLIS3, PROX1, FADS1, C2CD4B, IGF1 and IRS1 in a population-based cohort including 3,210 unrelated Chinese Hans from Beijing and Shanghai.ResultsWe confirmed the associations of GLIS3-rs7034200 with fasting glucose (beta = 0.07 mmol/l, P = 0.03), beta cell function (HOMA-B) (beta = -3.03%, P = 0.009), and type 2 diabetes (OR [95%CI] = 1.27 [1.09-1.49], P = 0.003) after adjustment for age, sex, region and BMI. The association for type 2 diabetes remained significant after adjusting for other diabetes related risk factors including family history of diabetes, lipid profile, medication information, hypertension and life style factors, while further adjustment for HOMA-B abolished the association. The A-allele of CRY2-rs11605924 was moderately associated with increased risk of combined IFG/type 2 diabetes (OR [95%CI] = 1.15[1.01-1.30], P = 0.04). SNPs in or near MADD, ADRA2A, PROX1, FADS1, C2CD4B, IGF1, and IRS1 did not exhibit significant associations with type 2 diabetes or related glycemic traits (P≥0.10).ConclusionsIn conclusion, our results indicate the associations of GLIS3 locus with type 2 diabetes and impaired fasting glucose in Chinese Hans, partially mediated through impaired beta-cell function. In addition, we also found modest evidence for the association of CRY2-rs11605924 with combined IFG/type 2 diabetes."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0021464"xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Lin X."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Qi L."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Qi Q."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Gan W."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/author | "Loos R.J."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/pages | "e21464"xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/title | "Variants in GLIS3 and CRY2 are associated with type 2 diabetes and impaired fasting glucose in Chinese Hans."xsd:string |
http://purl.uniprot.org/citations/21747906 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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