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http://purl.uniprot.org/citations/21748712http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21748712http://www.w3.org/2000/01/rdf-schema#comment"

Introduction

The existence of antibodies to aquaporin-4 (AQP-4-ab) has identified neuromyelitis optica (NMO) and multiple sclerosis (MS) as different diseases. Although HLA-DRB1 alleles contribute to MS risk, recent studies suggest that HLA back-ground differs between patients with NMO or MS in non-Caucasians populations. Our study was aimed to analyze HLA-DRB1 distribution in Caucasians NMO patients.

Subjects and methods

We recruited a cohort of 22 NMO patients (73% were AQP-4-ab positive), 228 MS patients and 225 healthy controls from Spain and we genotyped the HLA-DRB1 locus. Then, we performed a pool analysis using reported data from 45 NMO patients (53% were AQP-4-ab positive), 156 MS patients and 310 healthy controls from Caucasian French population.

Results

In the Spanish cohort, NMO was associated with increased frequency of DRB1*10 allele compared with MS (odds ratio, OR = 15.1; 95% confidence interval, 95% CI = 3.26-69.84; p = 0.012). In the pooled analysis, by comparison with healthy controls, NMO was associated with increased frequency of DRB1*03 allele (OR = 2.27; 95% CI = 1.44-3.58; p < 0.0008) which was related to AQP-4-ab seropositivity (OR = 2.74; 95% CI = 1.58-4.77; p < 0.0008). By contrast, MS was associated with increased frequency of DRB1*15 allele (OR = 2.09; 95% CI = 1.62-2.68; p < 0.0008) and decreased frequency of DRB1*07 allele (OR = 0.58; 95% CI = 0.44-0.78; p < 0.0008).

Conclusions

Caucasian patients with NMO and MS have a different HLA-DRB1 allelic distribution. DRB1*03 allele seems to contribute to NMO seropositivity. Multicenter collaborative efforts are needed to adequately address the genetic contribution to NMO susceptibility."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Lopez de Munain A."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Saiz A."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Graus F."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Ramio-Torrenta L."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Villoslada P."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Blanco Y."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Casanova-Estruch B."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Casado-Chocan J.L."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Ercilla-Gonzalez G."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Fernandez-Bolanos Porras R."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Llufriu S."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Magraner M.J."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Mendibe-Bilbao M.M."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Ramo-Tello C."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Santos-Lasaosa S."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Segura-Bruna N."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Sepulveda-Gazquez M."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/author"Ucles-Sanchez A.J."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/name"Rev Neurol"xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/pages"146-152"xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/title"[HLA-DRB1 typing in Caucasians patients with neuromyelitis optica]."xsd:string
http://purl.uniprot.org/citations/21748712http://purl.uniprot.org/core/volume"53"xsd:string
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