| http://purl.uniprot.org/citations/21750099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21750099 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21750099 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular factors involved in mRNA degradation and translation repression can aggregate into cytoplasmic domains known as GW bodies or mRNA processing bodies (P-bodies). However, current understanding of P-bodies, especially the regulatory aspect, remains relatively fragmentary. To provide a framework for studying the mechanisms and regulation of P-body formation, maintenance, and disassembly, we compiled a list of P-body proteins found in various species and further grouped both reported and predicted human P-body proteins according to their functions. By analyzing protein-protein interactions of human P-body components, we found that many P-body proteins form complex interaction networks with each other and with other cellular proteins that are not recognized as P-body components. The observation suggests that these other cellular proteins may play important roles in regulating P-body dynamics and functions. We further used siRNA-mediated gene knockdown and immunofluorescence microscopy to demonstrate the validity of our in silico analyses. Our combined approach identifies new P-body components and suggests that protein ubiquitination and protein phosphorylation involving 14-3-3 proteins may play critical roles for post-translational modifications of P-body components in regulating P-body dynamics. Our analyses provide not only a global view of human P-body components and their physical interactions but also a wealth of hypotheses to help guide future research on the regulation and function of human P-bodies."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.2789611"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.2789611"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/author | "Chen C.Y."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/author | "Chen C.Y."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/author | "Shyu A.B."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/author | "Shyu A.B."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/pages | "1619-1634"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/pages | "1619-1634"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/title | "Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/title | "Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation."xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/21750099 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21750099 |
| http://purl.uniprot.org/citations/21750099 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21750099 |
| http://purl.uniprot.org/citations/21750099 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21750099 |
| http://purl.uniprot.org/citations/21750099 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21750099 |