| http://purl.uniprot.org/citations/21750151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21750151 | http://www.w3.org/2000/01/rdf-schema#comment | "PRDM9 is a major specifier of human meiotic recombination hotspots, probably via binding of its zinc-finger repeat array to a DNA sequence motif associated with hotspots. However, our view of PRDM9 regulation, in terms of motifs defined and hotspots studied, has a strong bias toward the PRDM9 A variant particularly common in Europeans. We show that population diversity can reveal a second class of hotspots specifically activated by PRDM9 variants common in Africans but rare in Europeans. These African-enhanced hotspots nevertheless share very similar properties with their counterparts activated by the A variant. The specificity of hotspot activation is such that individuals with differing PRDM9 genotypes, even within the same population, can use substantially if not completely different sets of hotspots. Each African-enhanced hotspot is activated by a distinct spectrum of PRDM9 variants, despite the fact that all are predicted to bind the same sequence motif. This differential activation points to complex interactions between the zinc-finger array and hotspots and identifies features of the array that might be important in controlling hotspot activity."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1109531108"xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/author | "Neumann R."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/author | "Jeffreys A.J."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/author | "Berg I.L."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/author | "Odenthal-Hesse L."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/author | "Sarbajna S."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/author | "Butler N.J."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/pages | "12378-12383"xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/title | "Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations."xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21750151 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21750151 |
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