| http://purl.uniprot.org/citations/21751159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21751159 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen (HLA) plays a central role in the regulation of the immune response. HLA class II molecules are essential for T cell-mediated adaptive immunity and present peptide antigens to CD4(+) T cells. Because of its important role in the immune response and its high degree of polymorphism, the HLA system is associated with many diseases. We examined the polymorphisms of HLA-DRB alleles and the sequences of the HLA-DRB promoter region in 97 unrelated patients with pulmonary tuberculosis and in 62 unrelated normal controls of the Han nationality from North China, using PCR with sequence-specific primers and PCR direct sequencing. We found that the frequency of HLA-DRB1*15 was significantly higher in the pulmonary tuberculosis group than in the healthy control group. The P value was 0.001, and the odds ratio was 3.793. The pulmonary tuberculosis group had the same HLA-DRB1 promoter region sequences as the control group. We concluded that the HLA-DRB1*15 allele is associated with pulmonary tuberculosis in the Han nationality from North China. The HLA-DRB1 promoter region sequences had no association with the development of pulmonary tuberculosis."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.org/dc/terms/identifier | "doi:10.4238/vol10-3gmr1132"xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/author | "Hu X.L."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/author | "Guo Y.L."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/author | "Song C.X."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/author | "Shi G.L."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/author | "Rong C.L."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/name | "Genet Mol Res"xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/pages | "1331-1336"xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/title | "Association of HLA-DRB alleles and pulmonary tuberculosis in North Chinese patients."xsd:string |
| http://purl.uniprot.org/citations/21751159 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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