| http://purl.uniprot.org/citations/21753146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21753146 | http://www.w3.org/2000/01/rdf-schema#comment | "Galectin (Gal) family members are a type of soluble lectin, and they play important roles in immunomodulation. Their redundant roles have been proposed. We previously found that Gal-1 promotes the formation of Ab-secreting plasma cells, but B cells from Gal-1-deficient and control animals produce comparable amounts of Abs. In the current study, we used synthetic sulfomodified N-acetyllactosamine (LacNAc) analogs and short hairpin RNAs for Gal-8 to demonstrate a redundancy in the effects of Gal-1 and Gal-8 on plasma cell formation. Gal-1 and Gal-8 were both expressed during plasma cell differentiation, and both Gals promoted the formation of plasma cells. Gal-1 and Gal-8 bound better to mature B cells than to plasma cells, and the expression of glycosyltransferase enzymes changed during differentiation, with a decrease in mannosyl (α-1,6-)-glycoprotein β-1,6-N-acetyl-glucosaminyltransferase and N-acetylglucosaminyltransferase-1 mRNAs in plasma cells. Synthetic sulfomodified Galβ1-3GlcNAc disaccharides (type 1 LacNAcs) selectively prevented Gal-8 binding, leading to a blockade of Ab production in Gal-1-deficient B cells. Furthermore, synthetic type 1 LacNAcs that were able to block the binding of both Gals greatly reduced the effect of exogenously added recombinant Gal-1 and Gal-8 on promoting Ab production. These results reveal a novel role for Gal-8 in collaboration with Gal-1 in plasma cell formation, and suggest the possibility of using distinct LacNAc ligands to modulate the function of Gals."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1100297"xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Lin C.H."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Tu Z."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Wu K.J."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Tsai C.M."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Hsu T.L."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Lin K.I."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Guan C.H."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/author | "Hsieh H.W."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/pages | "1643-1652"xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/title | "Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation."xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/21753146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21753146 |
| http://purl.uniprot.org/citations/21753146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21753146 |
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| http://purl.uniprot.org/uniprot/P16045#attribution-42F527B205911B15BC66CC6F0C47D6B7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21753146 |
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| http://purl.uniprot.org/uniprot/#_P16045-mappedCitation-21753146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21753146 |
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