| http://purl.uniprot.org/citations/21756875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21756875 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucagon-like peptide 1 (GLP-1), an insulinotropic gastrointestinal peptide produced mainly from intestinal endocrine L-cells, and liraglutide, a GLP-1 receptor (GLP-1R) agonist, induce satiety. The serotonin 5-HT2C receptor (5-HT2CR) and melanoroctin-4 receptor (MC4R) are involved in the regulation of food intake. Here we show that systemic administration of GLP-1 (50 and 200μg/kg)-induced anorexia was blunted in mice with a 5HT2CR null mutation, and was attenuated in mice with a heterozygous MC4R mutation. On the other hand, systemic administration of liraglutide (50 and 100μg/kg) suppressed food intake in mice lacking 5-HT2CR, mice with a heterozygous mutation of MC4R and wild-type mice matched for age. Moreover, once-daily consecutive intraperitoneal administration of liraglutide (100μg/kg) over 3days significantly suppressed daily food intake and body weight in mice with a heterozygous mutation of MC4R as well as wild-type mice. These findings suggest that GLP-1 and liraglutide induce anorexia via different central pathways."xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.06.175"xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/author | "Nonogaki K."xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/author | "Tamari T."xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/author | "Wakameda M."xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/author | "Sanuki M."xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/pages | "445-448"xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/title | "The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liraglutide, a glucagon-like peptide 1 receptor agonist, in mice."xsd:string |
| http://purl.uniprot.org/citations/21756875 | http://purl.uniprot.org/core/volume | "411"xsd:string |
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