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| http://purl.uniprot.org/citations/21765619 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia frequently associated with certain physiologic and pathologic conditions influences numerous cellular functions. Because the effects of short-term hypoxia are incompletely understood, we examined phagocytosis and cytokine production as well as the activation of the transcription factors HIF-1 and NFκB in peripheral blood cells of healthy volunteers exposed to an oxygen concentration equivalent to that found at a height of 5500 m. Furthermore, we analysed plasma HIF-1 and serum concentrations of various HIF-1-dependent genes. Results showed that short-term hypoxia increased phagocytosis in neutrophils without affecting monocyte phagocytosis. Hypoxia decreased basal TNFα concentration in monocytes and basal interferon γ concentration in CD4(+) T lymphocytes. In contrast, plasma HIF and serum VEGF concentrations were not affected by hypoxia, although serum EPO concentration was raised. In PBMC, hypoxia increased cytosolic HIF-1 concentration without affecting nuclear HIF-1 concentration and led to a rise in the nuclear NFκB in PBMC. Our results show that short-term hypoxia affects immune functions in healthy individuals. Furthermore, we speculate that the effects of hypoxia are not due to HIF-1, but are caused by the activation of NFκB ."xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.org/dc/terms/identifier | "doi:10.1155/2011/429501"xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/author | "Jung C."xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/author | "Figulla H.R."xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/author | "Fritzenwanger M."xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/author | "Goebel B."xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/author | "Lauten A."xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/name | "Mediators Inflamm"xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/pages | "429501"xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/title | "Impact of short-term systemic hypoxia on phagocytosis, cytokine production, and transcription factor activation in peripheral blood cells."xsd:string |
| http://purl.uniprot.org/citations/21765619 | http://purl.uniprot.org/core/volume | "2011"xsd:string |
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