| http://purl.uniprot.org/citations/21765928 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21765928 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundSrc homology 2 (SH2) domain is a conserved module involved in various biological processes. Tensin family member was reported to be involved in tumor suppression by interacting with DLC-1 (deleted-in-liver-cancer-1) via its SH2 domain. We explore here the important questions that what the structure of tensin2 SH2 domain is, and how it binds to DLC-1, which might reveal a novel binding mode.Principal findingsTensin2 SH2 domain adopts a conserved SH2 fold that mainly consists of five β-strands flanked by two α-helices. Most SH2 domains recognize phosphorylated ligands specifically. However, tensin2 SH2 domain was identified to interact with nonphosphorylated ligand (DLC-1) as well as phosphorylated ligand.ConclusionsWe determined the solution structure of tensin2 SH2 domain using NMR spectroscopy, and revealed the interactions between tensin2 SH2 domain and its ligands in a phosphotyrosine-independent manner."xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0021965"xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/author | "Tu X."xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/author | "Liao S."xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/author | "Dai K."xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/pages | "e21965"xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/title | "Solution structure of tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1."xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21765928 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21765928 |
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