| http://purl.uniprot.org/citations/2176635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2176635 | http://www.w3.org/2000/01/rdf-schema#comment | "Intramolecular and intermolecular snRNA cross-links were generated by irradiating HeLa nuclear extract with 365 nm light in the presence of the psoralen derivative AMT. After deproteinization, cross-linked RNAs were resolved by gel electrophoresis and identified as anomalously migrating species by Northern blotting. In addition to the U4/U6 snRNA cross-link, we detected an intermolecular U2/U6 cross-link, as well as several apparently intramolecular U1, U2, and U5 cross-links. Photoreversal of the U2/U6 cross-link with 254 nm irradiation released stoichiometric amounts of U2 and U6 snRNA. To localize the U2/U6 cross-link, the 3' end of U2 in the purified U2/U6 complex was labeled selectively using a novel oligonucleotide "splint" technique. The labeled U2/U6 complex was then subjected to rapid enzymatic RNA sequencing or to targeted digestion of the U2 and U6 components of the complex by RNase H and a panel of complementary oligonucleotides. The U2/U6 cross-link is located upstream of nucleotide 15 in U2 and downstream of nucleotide 85 in U6, suggesting that the phylogenetically conserved base-pairing between these regions (6 consecutive base pairs in human, Drosophila melanogaster, and Caenorhabditis elegans, 7 in Schizosaccharomyces pombe and Trypanasoma brucei, 8 in Pisum sativum, 11 in Saccharomyces cerevisiae) is significant."xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.4.12a.2146"xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/author | "Weiner A.M."xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/author | "Giglio L.M."xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/author | "Hausner T.P."xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/pages | "2146-2156"xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/title | "Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles."xsd:string |
| http://purl.uniprot.org/citations/2176635 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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