| http://purl.uniprot.org/citations/21768361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21768361 | http://www.w3.org/2000/01/rdf-schema#comment | "Human cytomegalovirus induces and requires fatty acid synthesis. This suggests an essential role for lipidome remodeling in viral replication. We used mass spectrometry to quantify glycerophospholipids in mock-infected and virus-infected fibroblasts, as well as in virions. Although the lipid composition of mock-infected and virus-infected fibroblasts was similar, virions were markedly different. The virion envelope contained twofold more phosphatidylethanolamines and threefold less phosphatidylserines than the host cell. This indicates that the virus buds from a membrane with a different lipid composition from the host cell as a whole. Compared with published datasets, the virion envelope showed the greatest similarity to the synaptic vesicle lipidome. Synaptosome-associated protein of 25 kDa (SNAP-25) is a component of the complex that mediates exocytosis of synaptic vesicles in neurons; and its homolog, SNAP-23, functions in exocytosis in many other cell types. Infection induced the relocation of SNAP-23 to the cytoplasmic viral assembly zone, and knockdown of SNAP-23 inhibited the production of virus. We propose that cytomegalovirus capsids acquire their envelope by budding into vesicles with a lipid composition similar to that of synaptic vesicles, which subsequently fuse with the plasma membrane to release virions from the cell."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1109796108"xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Shenk T."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Brown H.A."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Rabinowitz J.D."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Liu S.T."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Milne S.B."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Myers D.S."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Ivanova P."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/author | "Sharon-Friling R."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/pages | "12869-12874"xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/title | "Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress."xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21768361 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21768361 |
| http://purl.uniprot.org/citations/21768361 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21768361 |
| http://purl.uniprot.org/uniprot/#_A8K287-mappedCitation-21768361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21768361 |
| http://purl.uniprot.org/uniprot/#_O00161-mappedCitation-21768361 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21768361 |
| http://purl.uniprot.org/uniprot/A8K287 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21768361 |
| http://purl.uniprot.org/uniprot/O00161 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21768361 |