| http://purl.uniprot.org/citations/21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21779788 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocyte Growth Factor (HGF) and its receptor c-Met are suggested to play an important role in progression of solid organ tumors by mediating cell motility, invasion and metastasis. Overexpression of HGF and c-Met have been shown in non-small-cell lung cancer (NSCLC). However, their role in tumor progression is not clearly defined. The aim of this study is to determine the role of HGF/c-Met pathway and its association with invasion related markers and clinicopathologic parameters in NSCLC. Immunohistochemical analysis was performed on 63 paraffin-embedded NSCLC tumor sections. The expressions of invasion related markers such as Matrix Metalloproteinases (MMPs) 2 and 9, Tissue Inhibitor Metalloproteinase (TIMP) 1 and 3 and RhoA were also examined. Co-expression of HGF/c-Met was significantly associated with lymph node invasion and TIMP-3 and RhoA overexpressions. There were positive correlation between TIMP-3 overexpression and advanced stage and negative correlation between RhoA overexpression and survival. DNA sequencing for Met mutations in both nonkinase and tyrosine kinase (TK) domain was established. A single nucleotide polymorphism (SNP) in sema domain and two SNPs in TK domain of c-Met were found. There was no statistically significant correlation between the presence of c-Met alterations and clinicopathologic parameters except shorter survival time in cases with two SNPs in TK domain. These results suggest that HGF/c-Met might exert their effects in tumor progression in association with RhoA and probably with TIMP-3. The blockade of the HGF/c-Met pathway with RhoA and/or TIMP-3 inhibitors may be an effective therapeutic target for NSCLC treatment."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12253-011-9430-7"xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/author | "Oztop I."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/author | "Ulukus C."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/author | "Atabey N."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/author | "Bulut G."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/author | "Kargi A."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/author | "Gozukizil A."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/author | "Gumustekin M."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/name | "Pathol Oncol Res"xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/pages | "209-218"xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/title | "HGF/c-Met overexpressions, but not met mutation, correlates with progression of non-small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/21779788 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21779788 |
| http://purl.uniprot.org/citations/21779788 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21779788 |
| http://purl.uniprot.org/uniprot/#_A0A024R324-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |
| http://purl.uniprot.org/uniprot/#_P61586-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK12-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |
| http://purl.uniprot.org/uniprot/#_A5D6Q9-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |
| http://purl.uniprot.org/uniprot/#_A0A7I2YQV1-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |
| http://purl.uniprot.org/uniprot/#_B4DKN9-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |
| http://purl.uniprot.org/uniprot/#_B5A935-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |
| http://purl.uniprot.org/uniprot/#_B5A936-mappedCitation-21779788 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21779788 |