http://purl.uniprot.org/citations/21784300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21784300 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveA potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a Child Behavior Checklist profile, comprising the Attention Problems, Anxious/Depressed, and Aggressive Behavior clinical subscales (CBCL-DP). The CBCL-DP indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. We have conducted a genome-wide association study of the CBCL-DP in children with attention-deficit/hyperactivity disorder (ADHD).MethodFamilies were ascertained at Massachusetts General Hospital and University of California, Los Angeles. Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. Genome-wide association analyses were conducted with the MQFAM multivariate extension of PLINK.ResultsCBCL data were available for 341 ADHD offspring from 339 ADHD affected trio families from the UCLA (N = 128) and the MGH (N = 213) sites. We found no genome-wide statistically significant associations but identified several plausible candidate genes among findings at p < 5E-05: TMEM132D, LRRC7, SEMA3A, ALK, and STIP1.ConclusionsWe found suggestive evidence for developmentally expressed genes operant in hippocampal dependent memory and learning with the CBCL-DP."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jaac.2011.05.001"xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Smalley S."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "McCracken J."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Loo S."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Faraone S.V."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Biederman J."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Doyle A.E."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Mick E."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "McGough J."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Wozniak J."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/author | "Wilens T.E."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/name | "J Am Acad Child Adolesc Psychiatry"xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/pages | "807-17.e8"xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/title | "Genome-wide association study of the child behavior checklist dysregulation profile."xsd:string |
http://purl.uniprot.org/citations/21784300 | http://purl.uniprot.org/core/volume | "50"xsd:string |
http://purl.uniprot.org/citations/21784300 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21784300 |
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