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http://purl.uniprot.org/citations/21784424http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21784424http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Arterial stiffness predicts an increased risk of future cardiovascular events, possibly via myocardial damage. Minimally elevated levels of plasma cardiac troponin T (TnT), a marker of cardiomyocyte injury, can be detected by the high-sensitivity TnT (hsTnT) assay. The current study investigated the relationship between plasma hsTnT levels and alterations in arterial stiffness in a community-based population.

Methods

We related levels of plasma hsTnT to measures of arterial stiffness (carotid-femoral pulse wave velocity [PWV], office pulse pressure [PP] and carotid-radial PWV) in 1479 participants (mean age, 62.3 years; 619 men, 860 women) from a community-based population in Beijing, China.

Results

In multiple logistic regression models, carotid-femoral PWV (OR: 1.84; 95% CI: 1.06-3.17; P=0.028) and office PP (OR: 2.02; 95% CI: 1.31-3.11; P=0.002) were associated with a higher likelihood of detectable hsTnT. In addition, carotid-femoral PWV (OR: 2.34; 95% CI: 1.03-5.30; P=0.042) and office PP (OR: 2.30; 95% CI: 1.13-4.66; P=0.022) were significantly related to elevated hsTnT levels. A subsequent subgroup analysis found that, in subjects aged 60 years and older, the associations between carotid-femoral PWV and office PP and hsTnT levels were strengthened. The associations between hsTnT with any of the arterial stiffness measures were not present in the younger subgroup (<60 years old).

Conclusions

Carotid-femoral PWV and office PP are associated with minimally elevated hsTnT levels in the elderly, indicating a relationship between central artery stiffness and subclinical myocardial damage."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.org/dc/terms/identifier"doi:10.1016/j.atherosclerosis.2011.06.035"xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/author"Bai Y."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/author"Luo L."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/author"Wu H."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/author"Xu R."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/author"Xiao W."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/author"Bai J."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/author"Ye P."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/name"Atherosclerosis"xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/pages"493-498"xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/title"Arterial stiffness is associated with minimally elevated high-sensitivity cardiac, troponin T levels in a community-dwelling population."xsd:string
http://purl.uniprot.org/citations/21784424http://purl.uniprot.org/core/volume"218"xsd:string
http://purl.uniprot.org/citations/21784424http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21784424
http://purl.uniprot.org/citations/21784424http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21784424
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http://purl.uniprot.org/uniprot/Q56R93http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21784424
http://purl.uniprot.org/uniprot/Q05DL6http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21784424
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