| http://purl.uniprot.org/citations/21784897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21784897 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased expression of Induced-by-High-Glucose 1 (IHG-1) associates with tubulointerstitial fibrosis in diabetic nephropathy. IHG-1 amplifies TGF-β1 signaling, but the functions of this highly-conserved protein are not well understood. IHG-1 contains a putative mitochondrial-localization domain, and here we report that IHG-1 is specifically localized to mitochondria. IHG-1 overexpression increased mitochondrial mass and stabilized peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). Conversely, inhibition of IHG-1 expression decreased mitochondrial mass, downregulated mitochondrial proteins, and PGC-1α-regulated transcription factors, including nuclear respiratory factor 1 and mitochondrial transcription factor A (TFAM), and reduced activity of the TFAM promoter. In the unilateral ureteral obstruction model, we observed higher PGC-1α protein expression and IHG-1 levels with fibrosis. In a gene-expression database, we noted that renal biopsies of human diabetic nephropathy demonstrated higher expression of genes encoding key mitochondrial proteins, including cytochrome c and manganese superoxide dismutase, compared with control biopsies. In summary, these data suggest that IHG-1 increases mitochondrial biogenesis by promoting PGC-1α-dependent processes, potentially contributing to the pathogenesis of renal fibrosis."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2010111154"xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Murphy M."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Martin F."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Godson C."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Bhreathnach U."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Corcoran J.B."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Furlong F."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Griffin B."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Hickey F.B."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/author | "Docherty N.G."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/pages | "1475-1485"xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/title | "IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1alpha."xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/21784897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21784897 |
| http://purl.uniprot.org/citations/21784897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21784897 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AWK0-mappedCitation-21784897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784897 |
| http://purl.uniprot.org/uniprot/#_A0A8L2Q1Y2-mappedCitation-21784897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784897 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y905-mappedCitation-21784897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784897 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A531-mappedCitation-21784897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784897 |
| http://purl.uniprot.org/uniprot/#_B4E366-mappedCitation-21784897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784897 |
| http://purl.uniprot.org/uniprot/#_Q9QYK2-mappedCitation-21784897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784897 |