| http://purl.uniprot.org/citations/21784968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21784968 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein A (SP-A) regulates a variety of immune cell functions. We determined the ability of SP-A derived from normal and asthmatic subjects to modulate the inflammatory response elicited by Mycoplasma pneumoniae, a pathogen known to exacerbate asthma. Fourteen asthmatic and 10 normal control subjects underwent bronchoscopy with airway brushing and bronchoalveolar lavage (BAL). Total SP-A was extracted from BAL. The ratio of SP-A1 to total SP-A (SP-A1/SP-A) and the binding of total SP-A to M. pneumoniae membranes were determined. Airway epithelial cells from subjects were exposed to either normal or asthmatic SP-A before exposure to M. pneumoniae. IL-8 protein and MUC5AC mRNA were measured. Total BAL SP-A concentration did not differ between groups, but the percentage SP-A1 was significantly increased in BAL of asthmatic compared with normal subjects. SP-A1/SP-A significantly correlated with maximum binding of total SP-A to M. pneumoniae, but only in asthma. SP-A derived from asthmatic subjects did not significantly attenuate IL-8 and MUC5AC in the setting of M. pneumoniae infection compared with SP-A derived from normal subjects. We conclude that SP-A derived from asthmatic subjects does not abrogate inflammation effectively, and this dysfunction may be modulated by SP-A1/SP-A."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00381.2010"xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Voelker D.R."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Wright J.R."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Floros J."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Chu H.W."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Kraft M."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Kandasamy P."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Ingram J.L."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Church T.D."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Fertel D."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/author | "Lugogo N.L."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/pages | "L598-606"xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/title | "Surfactant protein A is defective in abrogating inflammation in asthma."xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://purl.uniprot.org/core/volume | "301"xsd:string |
| http://purl.uniprot.org/citations/21784968 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21784968 |
| http://purl.uniprot.org/citations/21784968 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21784968 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DG36-mappedCitation-21784968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784968 |
| http://purl.uniprot.org/uniprot/#_B7Z4Y4-mappedCitation-21784968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784968 |
| http://purl.uniprot.org/uniprot/#_B4DNP6-mappedCitation-21784968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21784968 |