| http://purl.uniprot.org/citations/21785410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21785410 | http://www.w3.org/2000/01/rdf-schema#comment | "Spindle pole bodies (SPBs), like nuclear pore complexes, are embedded in the nuclear envelope (NE) at sites of fusion of the inner and outer nuclear membranes. A network of interacting proteins is required to insert a cytoplasmic SPB precursor into the NE. A central player of this network is Nbp1 that interacts with the conserved integral membrane protein Ndc1. Here, we establish that Nbp1 is a monotopic membrane protein that is essential for SPB insertion at the inner face of the NE. In vitro and in vivo studies identified an N-terminal amphipathic α-helix of Nbp1 as a membrane-binding element, with crucial functions in SPB duplication. The karyopherin Kap123 binds to a nuclear localization sequence next to this amphipathic α-helix and prevents unspecific tethering of Nbp1 to membranes. After transport into the nucleus, Nbp1 binds to the inner nuclear membrane. These data define the targeting pathway of a SPB component and suggest that the amphipathic α-helix of Nbp1 is important for SPB insertion into the NE from within the nucleus."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.242"xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Kupke T."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Wieland F."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Schiebel E."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Adolf F."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Muller H.M."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Neuner A."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Nickel W."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/author | "Di Cecco L."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/pages | "3337-3352"xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/title | "Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication."xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21785410 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21785410 |
| http://purl.uniprot.org/citations/21785410 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21785410 |
| http://purl.uniprot.org/uniprot/P52919#attribution-7A21AC22B7549411D6E30E10A2224079 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21785410 |
| http://purl.uniprot.org/uniprot/P52919#attribution-8C3887FA30F750BBD7F674867B274338 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21785410 |
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| http://purl.uniprot.org/uniprot/#_A0A8H4F8N5-mappedCitation-21785410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21785410 |
| http://purl.uniprot.org/uniprot/#_A0A8H8ULX5-mappedCitation-21785410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21785410 |
| http://purl.uniprot.org/uniprot/#_B5VKC0-mappedCitation-21785410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21785410 |
| http://purl.uniprot.org/uniprot/#_P21560-mappedCitation-21785410 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21785410 |