| http://purl.uniprot.org/citations/21787615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21787615 | http://www.w3.org/2000/01/rdf-schema#comment | "We hypothesized that fluoride induces vascular contraction through activation of the RhoA/Rho kinase pathway in isolated rat aortas. Rat aortic rings were mounted in organ baths and contracted with sodium fluoride (NaF). We measured the amount of GTP-RhoA as well as vascular tension. We also determined the level of phosphorylation of the myosin light chain (MLC(20)), myosin phosphatase targeting subunit 1 (MYPT1) and PKC-potentiated inhibitory protein for heterotrimeric MLCP of 17kDa (CPI17). In both physiological salt solution and Ca(2+)-free solution, NaF increased vascular tension and MLC(20) phosphorylation in dose-dependent manners. NaF increased not only phosphorylation level of MYPT1(Thr855) and CPI17(Thr38), but also the amount of GTP-RhoA. Both H1152 and Y27632, inhibitors of Rho kinase, but not Ro31-8220, an inhibitor of PKC, attenuated NaF-induced contraction and phosphorylation level of MLC(20), MYPT1(Thr855) and CPI17(Thr38). In conclusion, fluoride induces vascular contraction through activation of the RhoA/Rho kinase pathway."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.etap.2010.02.004"xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/author | "Yang E."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/author | "Kim I.K."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/author | "Song M.J."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/author | "Baek I."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/author | "Jeon S.B."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/author | "Yoon Y.R."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/name | "Environ Toxicol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/pages | "290-296"xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/title | "Fluoride induces vascular contraction through activation of RhoA/Rho kinase pathway in isolated rat aortas."xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/21787615 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21787615 |
| http://purl.uniprot.org/citations/21787615 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21787615 |
| http://purl.uniprot.org/uniprot/#_Q10728-mappedCitation-21787615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21787615 |
| http://purl.uniprot.org/uniprot/#_Q99MC0-mappedCitation-21787615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21787615 |
| http://purl.uniprot.org/uniprot/Q10728 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21787615 |
| http://purl.uniprot.org/uniprot/Q99MC0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21787615 |