| http://purl.uniprot.org/citations/21787766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21787766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21787766 | http://www.w3.org/2000/01/rdf-schema#comment | "Vertebrate Hox clusters contain protein-coding genes that regulate body axis development and microRNA (miRNA) genes whose functions are not yet well understood. We overexpressed the Hox cluster microRNA miR-196 in zebrafish embryos and found four specific, viable phenotypes: failure of pectoral fin bud initiation, deletion of the 6th pharyngeal arch, homeotic aberration and loss of rostral vertebrae, and reduced number of ribs and somites. Reciprocally, miR-196 knockdown evoked an extra pharyngeal arch, extra ribs, and extra somites, confirming endogenous roles of miR-196. miR-196 injection altered expression of hox genes and the signaling of retinoic acid through the retinoic acid receptor gene rarab. Knocking down rarab mimicked the pectoral fin phenotype of miR-196 overexpression, and reporter constructs tested in tissue culture and in embryos showed that the rarab 3'UTR is a miR-196 target for pectoral fin bud initiation. These results show that a Hox cluster microRNA modulates development of axial patterning similar to nearby protein-coding Hox genes, and acts on appendicular patterning at least in part by modulating retinoic acid signaling."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2011.07.014"xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Postlethwait J.H."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Postlethwait J.H."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Schartl M."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Schartl M."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Herpin A."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Herpin A."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Wagner T.U."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Wagner T.U."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Yan Y.L."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Yan Y.L."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Eberhart J.K."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/author | "Eberhart J.K."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/pages | "463-477"xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/pages | "463-477"xsd:string |
| http://purl.uniprot.org/citations/21787766 | http://purl.uniprot.org/core/title | "miR-196 regulates axial patterning and pectoral appendage initiation."xsd:string |