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http://purl.uniprot.org/citations/21788473http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21788473http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21788473http://www.w3.org/2000/01/rdf-schema#comment"A carbapenem-resistant Pseudomonas aeruginosa strain (PA41437) susceptible to expanded-spectrum cephalosporins was recovered from several consecutive lower-respiratory-tract specimens of a patient who developed a ventilator-associated pneumonia while hospitalized in an intensive care unit. Cloning experiments identified OXA-198, a new class D β-lactamase which was weakly related (less than 45% amino acid identity) to other class D β-lactamases. Expression in Escherichia coli TOP10 and in P. aeruginosa PAO1 led to transformants that were resistant to ticarcillin and showed reduced susceptibility to carbapenems and cefepime. The bla(OXA-198) gene was harbored by a class 1 integron carried by a ca. 46-kb nontypeable plasmid. This study describes a novel class D β-lactamase involved in carbapenem resistance in P. aeruginosa."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.org/dc/terms/identifier"doi:10.1128/AAC.00522-11"xsd:string
http://purl.uniprot.org/citations/21788473http://purl.org/dc/terms/identifier"doi:10.1128/aac.00522-11"xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Galleni M."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Galleni M."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Bebrone C."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Bebrone C."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Bogaerts P."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Bogaerts P."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Glupczynski Y."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"Glupczynski Y."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"El Garch F."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/author"El Garch F."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/name"Antimicrob. Agents Chemother."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/name"Antimicrob Agents Chemother"xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/pages"4828-4833"xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/pages"4828-4833"xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/title"OXA-198, an Acquired Carbapenem-Hydrolyzing Class D {beta}-Lactamase from Pseudomonas aeruginosa."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/title"OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa."xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/volume"55"xsd:string
http://purl.uniprot.org/citations/21788473http://purl.uniprot.org/core/volume"55"xsd:string