| http://purl.uniprot.org/citations/21789179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21789179 | http://www.w3.org/2000/01/rdf-schema#comment | "The major physiological function of milk is the transport of amino acids, carbohydrates, lipids and minerals to mammalian offspring. Caseins, the major milk proteins, are secreted in the form of a micelle consisting of protein and calcium-phosphate.We have analysed the role of the milk protein α-casein by inactivating the corresponding gene in mice. Absence of α-casein protein significantly curtails secretion of other milk proteins and calcium-phosphate, suggesting a role for α-casein in the establishment of casein micelles. In contrast, secretion of albumin, which is not synthesized in the mammary epithelium, into milk is not reduced. The absence of α-casein also significantly inhibits transcription of the other casein genes. α-Casein deficiency severely delays pup growth during lactation and results in a life-long body size reduction compared to control animals, but has only transient effects on physical and behavioural development of the pups. The data support a critical role for α-casein in casein micelle assembly. The results also confirm lactation as a critical window of metabolic programming and suggest milk protein concentration as a decisive factor in determining adult body weight."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0021775"xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Kolb A.F."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Lillico S.G."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Whitelaw C.B."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Robinson C.J."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Carlisle A."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Neil C."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Sorensen D.B."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Petrie L."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Olsson I.A."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/author | "Huber R.C."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/pages | "e21775"xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/title | "Milk lacking alpha-casein leads to permanent reduction in body size in mice."xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21789179 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21789179 |
| http://purl.uniprot.org/citations/21789179 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21789179 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGT8-mappedCitation-21789179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21789179 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JEN3-mappedCitation-21789179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21789179 |
| http://purl.uniprot.org/uniprot/#_Q99M19-mappedCitation-21789179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21789179 |
| http://purl.uniprot.org/uniprot/#_P19228-mappedCitation-21789179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21789179 |
| http://purl.uniprot.org/uniprot/#_Q3TP32-mappedCitation-21789179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21789179 |