| http://purl.uniprot.org/citations/21791599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21791599 | http://www.w3.org/2000/01/rdf-schema#comment | "In allo-HSCT, donor-derived, "alloreactive" NK cells have been shown to play a crucial role in the treatment of acute leukemia, contributing to eradication of leukemic blasts (GvL effect) and to clearance of residual recipient DCs and T lymphocytes (thus, preventing GvHD and graft rejection, respectively). Such alloreactive NK cells do not express CD94/NKG2A but express inhibitory KIRs, specific for HLA class I allotypes, present in the donor but lacking in the recipient. This review is focused on the role of the activating KIR2DS1 receptor (specific for the C2-epitope of HLA-C) in haplo-HSCT. Recent data indicate that KIR2DS1 expression in HSC donors may represent a remarkable advantage in alloreactive NK responses. This is a result of a substantial increase in the NK-mediated capability to kill, not only recipients' leukemic cells but also DCs and T cell blasts. The beneficial effects mediated by alloreactive KIR2DS1(+) NK cells may occur after de novo expression of CCR7 upon interaction with allogeneic, KIR ligand-mismatched CCR7(+) cells. As a consequence, they can be redirected to LNs, where they can prevent priming of donor T cells and induction of GvHD. Finally, KIR2DS1 expression may also significantly amplify the size of the alloreactive NK cell subset by switching a subset of "not alloreactive" NK cells into potent alloreactive cells."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0311137"xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/author | "Moretta A."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/author | "Marcenaro E."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/author | "Sivori S."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/author | "Della Chiesa M."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/author | "Pesce S."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/author | "Carlomagno S."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/pages | "661-667"xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/title | "Role of alloreactive KIR2DS1(+) NK cells in haploidentical hematopoietic stem cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://purl.uniprot.org/core/volume | "90"xsd:string |
| http://purl.uniprot.org/citations/21791599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21791599 |
| http://purl.uniprot.org/citations/21791599 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21791599 |
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