| http://purl.uniprot.org/citations/21803054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21803054 | http://www.w3.org/2000/01/rdf-schema#comment | "An intriguing novel pathophysiological insight into mood disorders is the notion that one's metabolic status influences mood. In rodents, cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/NUCB2 have not only been implicated in metabolism, but in the pathobiology of anxiety and depressive-like behaviour, however they have not previously been investigated in depressed subjects. Both peptides are highly expressed in centrally projecting neurons in the Edinger-Westphal nucleus (EWcp) in the midbrain. The EWcp has been implicated in stress adaptation and stress-related mood disorders like major depressive disorder in a sex-specific manner. This is intriguing, given the fact that females have higher prevalence of mood disorders. Here, we hypothesized that the expression of CART and nesfatin-1 in EWcp would exhibit a sex-specific difference between depressed suicide victims vs. controls. We found that CART and nesfatin/NUCB2 colocalized in the human EWcp, and that CART mRNA content was much higher in both male (×3.8) and female (×5.9) drug-free suicide victims than in controls (persons who died without any diagnosed neurodegenerative or psychiatric disorder). Similarly, NUCB2 mRNA content was also higher (×1.8) in male suicides, whereas in female suicide victims, these contents were ×2.7 lower compared to controls. These observations are the first to show changes in the dynamics of CART and nesfatin/NUCB2 expressions in the midbrain of drug-free depressed suicide victims vs. controls. This article is part of a Special Issue entitled 'Anxiety and Depression'."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuropharm.2011.07.023"xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/author | "Roubos E.W."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/author | "Palkovits M."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/author | "Morava E."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/author | "Kozicz T."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/author | "Faludi G."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/author | "Bloem B."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/name | "Neuropharmacology"xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/pages | "297-303"xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/title | "Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls."xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/21803054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21803054 |
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| http://purl.uniprot.org/uniprot/#_Q16568-mappedCitation-21803054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21803054 |
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