| http://purl.uniprot.org/citations/21803290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21803290 | http://www.w3.org/2000/01/rdf-schema#comment | "Age-related loss of muscle mass and force (sarcopenia) contributes to disability and increased mortality. Ryanodine receptor 1 (RyR1) is the skeletal muscle sarcoplasmic reticulum calcium release channel required for muscle contraction. RyR1 from aged (24 months) rodents was oxidized, cysteine-nitrosylated, and depleted of the channel-stabilizing subunit calstabin1, compared to RyR1 from younger (3-6 months) adults. This RyR1 channel complex remodeling resulted in "leaky" channels with increased open probability, leading to intracellular calcium leak in skeletal muscle. Similarly, 6-month-old mice harboring leaky RyR1-S2844D mutant channels exhibited skeletal muscle defects comparable to 24-month-old wild-type mice. Treating aged mice with S107 stabilized binding of calstabin1 to RyR1, reduced intracellular calcium leak, decreased reactive oxygen species (ROS), and enhanced tetanic Ca(2+) release, muscle-specific force, and exercise capacity. Taken together, these data indicate that leaky RyR1 contributes to age-related loss of muscle function."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2011.05.014"xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Zalk R."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Xie W."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Meli A.C."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Marks A.R."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Reiken S."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Shiomi T."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Lacampagne A."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Betzenhauser M.J."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Umanskaya A."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/author | "Andersson D.C."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/pages | "196-207"xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/title | "Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging."xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/21803290 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21803290 |
| http://purl.uniprot.org/citations/21803290 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21803290 |
| http://purl.uniprot.org/uniprot/#_E9PZQ0-mappedCitation-21803290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21803290 |
| http://purl.uniprot.org/uniprot/#_Q1JUQ6-mappedCitation-21803290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21803290 |
| http://purl.uniprot.org/uniprot/#_Q1JUQ7-mappedCitation-21803290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21803290 |
| http://purl.uniprot.org/uniprot/#_Q1JUQ8-mappedCitation-21803290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21803290 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQG7-mappedCitation-21803290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21803290 |