| http://purl.uniprot.org/citations/21803996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21803996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21803996 | http://www.w3.org/2000/01/rdf-schema#comment | "The control of mRNA stability is an important component of regulation in bacteria. Processing and degradation of mRNAs are initiated by an endonucleolytic attack, and the cleavage products are processively degraded by exoribonucleases. In many bacteria, these RNases, as well as RNA helicases and other proteins, are organized in a protein complex called the RNA degradosome. In Escherichia coli, the RNA degradosome is assembled around the essential endoribonuclease E. In Bacillus subtilis, the recently discovered essential endoribonuclease RNase Y is involved in the initiation of RNA degradation. Moreover, RNase Y interacts with other RNases, the RNA helicase CshA, and the glycolytic enzymes enolase and phosphofructokinase in a degradosome-like complex. In this work, we have studied the domain organization of RNase Y and the contribution of the domains to protein-protein interactions. We provide evidence for the physical interaction between RNase Y and the degradosome partners in vivo. We present experimental and bioinformatic data which indicate that the RNase Y contains significant regions of intrinsic disorder and discuss the possible functional implications of this finding. The localization of RNase Y in the membrane is essential both for the viability of B. subtilis and for all interactions that involve RNase Y. The results presented in this study provide novel evidence for the idea that RNase Y is the functional equivalent of RNase E, even though the two enzymes do not share any sequence similarity."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.05500-11"xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.05500-11"xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Lewis R.J."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Lewis R.J."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Herzberg C."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Herzberg C."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Newman J."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Newman J."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Rodrigues C."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Rodrigues C."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Stulke J."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Stulke J."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Commichau F.M."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Commichau F.M."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Lehnik-Habrink M."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Lehnik-Habrink M."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Rothe F.M."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Rothe F.M."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Solovyova A.S."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/author | "Solovyova A.S."xsd:string |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21803996 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |