| http://purl.uniprot.org/citations/21805468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21805468 | http://www.w3.org/2000/01/rdf-schema#comment | "NK cells eliminate cancer and virus-infected cells through their cytolytic activity. The last step in NK-cell cytotoxicity, resulting in exocytosis of granule content, requires fusion of lytic granules with the plasma membrane. Proteins from the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family mediate membrane fusion events in the cell. Here, we show that NK cells express all members of the R-SNARE subgroup. Two of these R-SNARE proteins, VAMP4 and VAMP7, colocalize with lytic granules during cytotoxic interactions. However, only VAMP7 associates with perforin-containing granules in nonactivated cells, indicating that the two VAMPs have different functions in exocytosis. Using both the tumor NK-cell line YTS and the peripheral NK cells, we show that the disruption of expression of either VAMP4 or VAMP7 inhibits the release of lytic granules and severely impairs NK-cell cytotoxic activity. Furthermore, VAMP7 but not VAMP4 is involved in IFN-γ secretion in NK cells, indicating that VAMP7 is involved in many fusion processes and thus plays a more general function in NK-cell activity than VAMP4."xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201141582"xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/author | "Strominger J.L."xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/author | "Krzewski K."xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/author | "Gil-Krzewska A."xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/author | "Watts J."xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/author | "Stern J.N."xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/pages | "3323-3329"xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/title | "VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells."xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21805468 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21805468 |
| http://purl.uniprot.org/citations/21805468 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21805468 |
| http://purl.uniprot.org/uniprot/#_B4DIH9-mappedCitation-21805468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/#_B4DMB4-mappedCitation-21805468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/#_B2R6P4-mappedCitation-21805468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/#_B4DE96-mappedCitation-21805468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/#_P51809-mappedCitation-21805468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/B4DE96 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/P51809 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/B4DMB4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/B2R6P4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21805468 |
| http://purl.uniprot.org/uniprot/B4DIH9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21805468 |