| http://purl.uniprot.org/citations/21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21807902 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Myc promotes cell growth by enhancing ribosomal biogenesis and translation. Deregulated expression of c-Myc and aberrant ribosomal biogenesis and translation contribute to tumorigenesis. Thus, a fine coordination between c-Myc and ribosomal biogenesis is vital for normal cell homeostasis. Here, we show that ribosomal protein L11 regulates c-myc mRNA turnover. L11 binds to c-myc mRNA at its 3' untranslated region (3'-UTR), the core component of microRNA-induced silencing complex (miRISC) argonaute 2 (Ago2), as well as miR-24, leading to c-myc mRNA reduction. Knockdown of L11 drastically increases the levels and stability of c-myc mRNA. Ablation of Ago2 abrogated the L11-mediated reduction of c-myc mRNA, whereas knockdown of L11 rescued miR-24-mediated c-myc mRNA decay. Interestingly, treatment of cells with the ribosomal stress-inducing agent actinomycin D or 5-fluorouracil significantly decreased the c-myc mRNA levels in an L11- and Ago2-dependent manner. Both treatments enhanced the association of L11 with Ago2, miR-24, and c-myc mRNA. We further show that ribosome-free L11 binds to c-myc mRNA in the cytoplasm and that this binding is enhanced by actinomycin D treatment. Together, our results identify a novel regulatory paradigm wherein L11 plays a critical role in controlling c-myc mRNA turnover via recruiting miRISC in response to ribosomal stress."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.05810-11"xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/author | "Dai M.S."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/author | "Sears R.C."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/author | "Sun X.X."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/author | "DeVine T."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/author | "Challagundla K.B."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/pages | "4007-4021"xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/title | "Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress."xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21807902 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21807902 |
| http://purl.uniprot.org/citations/21807902 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21807902 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |
| http://purl.uniprot.org/uniprot/#_B3CJ86-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |
| http://purl.uniprot.org/uniprot/#_B3CJ87-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |
| http://purl.uniprot.org/uniprot/#_B3CJ88-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |
| http://purl.uniprot.org/uniprot/#_B3CJB3-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |
| http://purl.uniprot.org/uniprot/#_B3CJB8-mappedCitation-21807902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21807902 |